WiNGS is a web-based analysis platform for Whole Exome / Whole Genome sequencing data. It is built as a federated ecosystem, where all senstivate data is kept on premise of registered users (e.g. a genetic center), and queried from a centralized user interface. This approach allows, amongst others, secure cross-center collaboration and anonymized statistical analysis. A simplified overview of the setup is shown here:
To setup WiNGS, we provide a manual here (mongoDB) and here (annotations). In order to finalize the setup, you will have to register in the central infrastructure as well. To do so, please contact us.
Several repositories are available under this account. They are organized as follows:
flowchart TD;
A[wings-public] --> B[CENTRAL INFRASTRUCTURE];
A --> C[FEDERATED INFRASTRCUTURE];
B --> D["wings_cdb<br/>-------<br/>Central MSSQL database"]
B --> E["wings_ui<br/>-------<br/>ASP.NET code of the Web-Interface"]
C --> F["wings_api_internal<br/>-------<br/>-Routines to communicate with central infrastructure<br/>-Routines to communicate with Annotation infrastructure<br/>-MongDB database"]
C --> G["wings_anno_api<br/>-------<br/>-Routines to manage annotation tasks<br/>-Optional, can be used centrally"]
G --> H["annotation_parser<br/>-------<br/>Routines to combine annotations from different subtasks"]
G --> I["vep_annotations<br/>-------<br/>Extended container to perform Ensmbel VEP"]
G --> J["cadd_annotations<br/>-------<br/>Extended container to perform cadd scoring"]
C --> K["wings_rstats<br/>-------<br/>R deployment to perform anonymized statistics"]
An overview of the capabilities of WiNGS is available on youtube
WiNGS is available under the GNU Affero General Public License Version 3
If you have questions, feel free to reach out at [email protected]