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@shawnrhoads shawnrhoads commented Sep 4, 2024

Based on the large DataFrame of time-resolved regression coefficients generated across all electrodes using statistics_utils.time_resolved_regression_single_channel(timeseries, regressors, standardize=True, smooth=False), can subselect rows for a given region of interest (e.g., 'AMY"):

roi_df = all_channels_df[all_channels_df.region == 'AMY'][['Original_Estimate', 'ts']]

Can run the following: roi_ttest, cluster_tstats = cluster_based_permutation(roi_df), which produces the following outputs:
- roi_ttest: DataFrame with t-statistics and p-values for each timepoint.
- cluster_tstats: DataFrame with summed t-statistics and timepoint range for each cluster identified.

cluster_based_permutation() relies on the following dependencies:

  • find_clusters()
  • ts_permutation_test() and ts_permutation_test()

It also depends on the following packages: pandas, numpy, scipy.stats.ttest_1samp, scipy.ndimage.label, joblib.Parallel, joblib.delayed, tqdm.tqdm

- need to figure out most efficient way to write `all_res['time']`
Based on the large DataFrame of time-resolved regression coefficients generated across all electrodes using `statistics_utils.time_resolved_regression_single_channel(timeseries, regressors, standardize=True, smooth=False)`, can subselect rows for a given region of interest (e.g., 'AMY"):
 ```
roi_df = all_channels_df[all_channels_df.region == 'AMY'][['Original_Estimate', 'ts']]
```

Can run the following: `roi_ttest, cluster_tstats = cluster_based_permutation(roi_df)`, which produces the following outputs:
    - roi_ttest: DataFrame with t-statistics and p-values for each timepoint.
    - cluster_tstats: DataFrame with summed t-statistics and timepoint range for each cluster identified.

`cluster_based_permutation()` relies on the following dependencies:
- `find_clusters()`
- `ts_permutation_test()` and `ts_permutation_test()`

It also depends on the following packages and functions: pandas (pd.DataFrame, groupby, apply, reset_index, loc), numpy (np.where, np.nan, np.abs, np.random.seed, np.random.permutation), scipy.stats (ttest_1samp), scipy.ndimage (label), joblib (Parallel, delayed), tqdm (tqdm)
@shawnrhoads shawnrhoads requested a review from seqasim September 4, 2024 17:25
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seqasim commented Sep 5, 2024

This mostly looks good but I don't think shuffling the 'ts' values of the regression outputs is exactly the right way to do this.

I think to mirror the original category-based permutations in Maris and Oostenveld 2007 I think we want to shuffle the regressors going into time_resolved_regression_single_channel, compute the clusters in this new surrogate output, and then compare that to the real cluster test stat

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3 participants