Welcome to the official GitHub organization for the Muscle Omics Laboratory, based at Guys Campus KCL in London (UK). Our research group focusses on developing and applying omic technologies to understand muscle and single muscle cells in healthy and diseased states. This work merges the fields of muscle biology, functional genomics and biophysics and aims to provide us with the most comprehensive and high-resolution understanding of how muscle cells behave and react in various contexts. Through these endeavours, we will be developing and modifying various analytical pipelines and packages. As a lab we are keen to ensure our code and analytical pipelines are shared and widely accessible. Through this GitHub organisation, we aim to do exactly that!

The Seaborne Lab seeks to understand how and why individual muscle cells (myofibers) behave the way they do. Myofibers are a uniquely specialised cell type, distinguished by their multinucleated architecture, which enables extraordinary plasticity and adaptability across health, development, and disease. We develop and apply cutting-edge muscle-omics and functional approaches to dissect the molecular programmes that govern myofiber regulation, protein function, and cellular behaviour. A central aim of our work is to understand how these finely tuned systems are remodelled by physiological stress and disrupted in disease. Our current research focuses on uncovering the origins of innate myofiber-to-myofiber heterogeneity and diversity, and defining how myofiber regulation becomes dysregulated during ageing, congenital muscle disorders, and neuromuscular diseases, including ALS and SMA.

Lab website: https://muscleomicslab.github.io/

PI website: https://www.kcl.ac.uk/people/robert-seaborne