Reuse the same site for different domains

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From @rallek

Thinking about multisites:

is it possible to have the same site (same database, theme, modules, ...) with different entry points?

e.g. www.mysite.tld do have the news module configured for index.php and myentrypoint.mysite.tld do have a configured content page for index.php?

This can be a usecase for my pggo.de site. Different sub-communities (e.g. a Kindergarden, a YMCA-group, ...) of the complete community do want to have their own subdomain or even main domain.