Results using one replicate

[idelvalle]

Hi,
Thanks a lot for creating this tool.
I am trying to test it with my data (I want to compare ref vs alt alleles), but I only have one replicate (one DNA and one RNA sample).
My dataset is composed of 70 variants (70 ref and 70 alt with 50 barcodes associated each)
I can not run mpralm using model_type = "corr_groups" since I get an error, does this mean I can use model_type = indep_groups to get results?

[pi-zz-a]

Hey @idelvalle , you're right you can use indep_groups. Just make sure to normalize your data in advance and setting normalize = FALSE, since the indep_groups doesn't use the replicate information.