Similar to https://github.com/LTLA/BiocNeighbors/issues/21, https://github.com/LTLA/csaw/issues/21, and https://github.com/LTLA/metapod/issues/1. See details of the failure on the Mac arm64 semiweekly report: https://bioconductor.org/checkResults/3.18/bioc-mac-arm64-LATEST/batchelor/kjohnson1-checksrc.html As a consequence, there's no Mac arm64 binary in BioC 3.18: https://bioconductor.org/packages/3.18/batchelor Thanks, H.