diff --git a/ITKSoftwareGuide.cmake b/ITKSoftwareGuide.cmake
index 2c2504ca..a54ddd06 100644
--- a/ITKSoftwareGuide.cmake
+++ b/ITKSoftwareGuide.cmake
@@ -16,7 +16,6 @@ find_package(ITK ${MINIMUM_ITK_VERSION} REQUIRED)
 if(Slicer_BUILD_${PROJECT_NAME})
   set(ITK_NO_IO_FACTORY_REGISTER_MANAGER 1) # Incorporate with Slicer nicely
 endif()
-include(${ITK_USE_FILE})
 
 if( NOT IS_DIRECTORY "${ITK_SOURCE_DIR}" )
   message(FATAL_ERROR "ITK source directory is not set :${ITK_SOURCE_DIR}:")
diff --git a/SoftwareGuide/CMakeLists.txt b/SoftwareGuide/CMakeLists.txt
index 9193c94f..d701c014 100644
--- a/SoftwareGuide/CMakeLists.txt
+++ b/SoftwareGuide/CMakeLists.txt
@@ -32,7 +32,6 @@ project(SoftwareGuide C)
 set(CMAKE_MODULE_PATH ${PROJECT_SOURCE_DIR}/CMake ${CMAKE_MODULE_PATH})
 
 find_package(ITK 5 REQUIRED)
-include(${ITK_USE_FILE})
 
 set(PDF_QUALITY_LEVEL "Screen" CACHE STRING "PDF Quality. Options are: Screen, Printer, PrePress")
 #
diff --git a/SoftwareGuide/Cover/Source/CMakeLists.txt b/SoftwareGuide/Cover/Source/CMakeLists.txt
index 2e9ae9b2..af7b806a 100644
--- a/SoftwareGuide/Cover/Source/CMakeLists.txt
+++ b/SoftwareGuide/Cover/Source/CMakeLists.txt
@@ -1,10 +1,9 @@
 cmake_minimum_required(VERSION 3.10.2 FATAL_ERROR)
 cmake_policy(VERSION 3.10.2)
- 
-project( VWSegmentation )
 
-find_package( ITK 5 REQUIRED )
-include( ${ITK_USE_FILE} )
+project(VWSegmentation)
+
+find_package(ITK 6 REQUIRED)
 
 set( operations
   VWHistogramRGB
@@ -23,5 +22,5 @@ set( operations
 
 foreach( operation ${operations} )
   add_executable( ${operation} ${operation}.cxx )
-  target_link_libraries( ${operation} ${ITK_LIBRARIES} )
+  target_link_libraries( ${operation} ${ITK_INTERFACE_LIBRARIES} )
 endforeach()
diff --git a/SoftwareGuide/Latex/Introduction/Installation.tex b/SoftwareGuide/Latex/Introduction/Installation.tex
index 3d7e924a..4857c736 100644
--- a/SoftwareGuide/Latex/Introduction/Installation.tex
+++ b/SoftwareGuide/Latex/Introduction/Installation.tex
@@ -51,13 +51,13 @@ \section{Obtaining the Software}%
 There are two different ways to access the ITK source code:
 \begin{description}
   \item[Periodic releases]{Official releases are available on the ITK web
-    site\footnote{\url{https://itk.org/ITK/resources/software.html}}.
+    site\footnote{\url{https://docs.itk.org/en/latest/download.html}}.
     They are released twice a year,
     and announced on the ITK web pages and discussion.
     However, they may not provide the latest and greatest features of the
     toolkit.}
   \item[Continuous repository checkout]{Direct access to the Git source code
-    repository\footnote{\url{https://itk.org/ITK.git}} provides immediate
+    repository\footnote{\url{https://github.com/InsightSoftwareConsortium/ITK.git}} provides immediate
     availability to the latest toolkit additions. But, on any given day the
     source code may not be stable as compared to the official releases.}
 \end{description}
@@ -79,7 +79,7 @@ \subsection{Downloading Packaged Releases}%
 
 ITK can be downloaded without cost from the following web site:
 \begin{center}
-  \url{https://www.itk.org/ITK/resources/software.html}
+  \url{https://docs.itk.org/en/latest/download.html}
 \end{center}
 
 On the web page, choose the tarball that better fits your system. The options are
@@ -104,7 +104,7 @@ \subsection{Downloading From Git}%
 
 Access ITK via Git using the following commands (under a Git Bash shell):
 \begin{minted}[baselinestretch=1,fontsize=\footnotesize,linenos=false,bgcolor=ltgray]{bash}
-git clone git://itk.org/ITK.git
+git clone https://github.com/InsightSoftwareConsortium/ITK
 \end{minted}
 
 This will trigger the download of the software into a directory named
@@ -129,7 +129,7 @@ \subsection{Data}%
 Another source of data can be obtained from the ITK Web site at either
 of the following:
 \begin{quote}
-\url{https://www.itk.org/ITK/resources/links.html} \\
+\url{https://docs.itk.org/en/latest/download.html} \\
 \url{ftp://public.kitware.com/pub/itk/Data/}.
 \end{quote}
 
@@ -574,9 +574,15 @@ \section{Using ITK as an External Library}%
 
 \small
 \begin{minted}[baselinestretch=1,fontsize=\footnotesize,linenos=false,bgcolor=ltgray]{cmake}
-set(MINIMUM_ITK_VERSION 5.4)
-find_package(ITK \${MINIMUM_ITK_VERSION} REQUIRED COMPONENTS Module1 Module2)
-include(\${ITK_USE_FILE})
+set(MINIMUM_ITK_VERSION 6.0)
+find_package(ITK ${MINIMUM_ITK_VERSION} REQUIRED
+  COMPONENTS
+    ITKCommon
+    ITKSmoothing
+  )
+
+add_executable(Example Example.cxx)
+target_link_libraries(Example ITK::ITKCommonModule ITK::ITKSmoothingModule)
 \end{minted}
 \normalsize
 
@@ -584,18 +590,64 @@ \section{Using ITK as an External Library}%
 
 \small
 \begin{minted}[baselinestretch=1,fontsize=\footnotesize,linenos=false,bgcolor=ltgray]{cmake}
-set(MINIMUM_ITK_VERSION 5.4)
-find_package(ITK \${MINIMUM_ITK_VERSION} REQUIRED
+set(MINIMUM_ITK_VERSION 6.0)
+find_package(ITK ${MINIMUM_ITK_VERSION} REQUIRED
   COMPONENTS
     MorphologicalContourInterpolation
     ITKSmoothing
     ITKIOImageBase
     ITKIONRRD
+  )
+
+add_executable(Example Example.cxx)
+target_link_libraries(Example
+  ITK::MorphologicalContourInterpolationModule
+  ITK::ITKSmoothingModule
+  ITK::ITKIOImageBaseModule
+  ITK::ITKIONRRDModule
+  )
+# or
+target_link_libraries(Example ${ITK_INTERFACE_LIBRARIES})
+\end{minted}
+\normalsize
+
+ITK uses factory registration to load IO formats and pluggable components at runtime.
+ITK 6 uses meta-modules that simplify factory registration by grouping related modules together.
+
+Factory meta-modules include:
+
+\begin{description}
+  \item[ITKImageIO] All image IO modules (JPEG, PNG, NIFTI, DICOM, etc.).
+  \item[ITKMeshIO] All mesh IO modules.
+  \item[ITKTransformIO] Transform IO modules.
+  \item[ITKFFTImageFilterInit] FFT implementations.
+\end{description}
+
+To register all factories:
+
+\small
+\begin{minted}[baselinestretch=1,fontsize=\footnotesize,linenos=false,bgcolor=ltgray]{cmake}
+set(MINIMUM_ITK_VERSION 6.0)
+find_package(ITK ${MINIMUM_ITK_VERSION} REQUIRED
+  COMPONENTS
+    MorphologicalContourInterpolation
+    ITKSmoothing
+    ITKImageIO
     )
-include(\${ITK_USE_FILE})
+itk_generate_factory_registration(ImageIO)
+
+add_executable(Example Example.cxx)
+target_link_libraries(Example ${ITK_INTERFACE_LIBRARIES} ITK::ITKImageIO)
 \end{minted}
 \normalsize
 
+The \code{itk\_generate\_factory\_registration()} macro must be called before adding executables.
+The CMake macro generates registration code for all the IO modules and factory-enabled components from
+the modules loaded in \code{find\_package()}. The \code{ITKImageIO}
+meta-module and \code{ITK::ITKImageIO} meta-interface target bring in all ITK
+image IO modules available in the build. The meta-interface target must be linked to the target to
+include and enable the generated registration code.
+
 If you would like to use the CMake ExternalProject
 Module\footnote{\url{https://cmake.org/cmake/help/latest/module/ExternalProject.html}}
 to download ITK source code when building your ITK application (a.k.a.
@@ -605,7 +657,7 @@ \section{Using ITK as an External Library}%
 \small
 \begin{minted}[baselinestretch=1,fontsize=\footnotesize,linenos=false,bgcolor=ltgray]{cmake}
 ExternalProject_Add(ITK
-      GIT_REPOSITORY \${git_protocol}://github.com/InsightSoftwareConsortium/ITK.git"
+      GIT_REPOSITORY https://github.com/InsightSoftwareConsortium/ITK.git"
       GIT_TAG "<tag id>" # specify the commit id or the tag id
       SOURCE_DIR <ITK source tree path>
       BINARY_DIR <ITK build tree path>
@@ -644,17 +696,18 @@ \subsection{Hello World!}%
 The \code{CMakeLists.txt} file contains the following lines:
 
 % CMake looks similar to bash with regards to formatting.
-\begin{minted}[linenos=false]{cmake}
+\small
+\begin{minted}[baselinestretch=1,fontsize=\footnotesize,linenos=false,bgcolor=ltgray]{cmake}
 project(HelloWorld)
 
-set(MINIMUM_ITK_VERSION 5.4)
-find_package(ITK \${MINIMUM_ITK_VERSION} REQUIRED)
-include(${ITK_USE_FILE})
+set(MINIMUM_ITK_VERSION 6.0)
+find_package(ITK ${MINIMUM_ITK_VERSION} REQUIRED)
+itk_generate_factory_registration()
 
 add_executable(HelloWorld HelloWorld.cxx)
-
-target_link_libraries(HelloWorld ${ITK_LIBRARIES})
+target_link_libraries(HelloWorld ${ITK_INTERFACE_LIBRARIES})
 \end{minted}
+\normalsize
 
 The first line defines the name of your project as it appears in Visual Studio
 or Eclipse; this line will have no effect with UNIX/Linux Makefiles. The second
@@ -663,9 +716,9 @@ \subsection{Hello World!}%
 corrected by providing the location of the directory where ITK was compiled or
 installed on your system. In this case the path to the ITK's binary/installation
 directory needs to be specified as the value of the \code{ITK\_DIR} CMake
-variable. The line \code{include(\$\{USE\_ITK\_FILE\})} loads the
-\code{UseITK.cmake} file which contains the configuration information about the
-specified ITK build. The line starting with \code{add\_executable} call defines
+variable. The line \code{itk\_generate\_factory\_registration()} generates configuration
+to enable input-output factory class registration in the subsequent executable.
+The line starting with \code{add\_executable} call defines
 as its first argument the name of the executable that will be produced
 as result of this project. The remaining argument(s) of \code{add\_executable}
 are the names of the source files to be compiled. Finally, the
diff --git a/SuperBuild/External_ITK.cmake b/SuperBuild/External_ITK.cmake
index 23ca0544..8c6b3aa2 100644
--- a/SuperBuild/External_ITK.cmake
+++ b/SuperBuild/External_ITK.cmake
@@ -104,8 +104,8 @@ if(NOT ( DEFINED "${extProjName}_DIR" OR ( DEFINED "USE_SYSTEM_${extProjName}" A
   ### --- End Project specific additions
   set(${proj}_REPOSITORY ${git_protocol}://github.com/InsightSoftwareConsortium/ITK.git)
   if("${${proj}_GIT_TAG}" STREQUAL "")
-    # ITK main branch 2025-09-24
-    set(${proj}_GIT_TAG "v6.0b01")
+    # ITK release branch 2026-02-25
+    set(${proj}_GIT_TAG "v6.0b02")
   endif()
 
   ExternalProject_Add(${proj}